Interferon-induced GTP-binding protein Mx1 was the first human restriction factor protein discovered, by Peter Staeheli, Otto Haller, and Charles Weissmann in 1986.
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5.3 Michael Malim — Discovery of APOBEC Restriction
(HIV/AIDS Research: Its History & Future Meeting)
... famously influenza virus, which is how it was discovered. (28) I should say the MX1 was the first viral restriction factor ever identified. Both proteins MX1 and MX2 are closely related to a human protein that’s got nothing to do with viruses ...
Apr 27, 2021
... famously influenza virus, which is how it was discovered. (28) I should say the MX1 was the first viral restriction factor ever identified. Both proteins MX1 and MX2 are closely related to a human protein that’s got nothing to do with viruses ...
Apr 27, 2021