Envelope glycoprotein gp120 is a glycoprotein exposed on the surface of the HIV envelope, and is encoded by the env gene. gp120 is the larger of two parts of the HIV envelope spike complex, along with gp41.
gp120 was discovered by Professors Tun-Hou Lee and Myron "Max" Essex of the Harvard School of Public Health in 1988. It is a key antigen used in HIV blood tests. Binding of gp120 to CD4 initiates the fusion of the virus into the host cell.
Found 13 search result(s) for gp120.
gp41
(HIV/AIDS Research: Its History & Future Meeting)
... Part of the HIV envelope spike complex, along with gp120. It is encoded by the HIV env gene
Feb 01, 2021
... Part of the HIV envelope spike complex, along with gp120. It is encoded by the HIV env gene
Feb 01, 2021
env
(HIV/AIDS Research: Its History & Future Meeting)
... found on the surface of the virus. In HIV, env encodes the protein gp160, which is cleaved into gp120 and gp41, making up the envelope spike complex that binds to CD4, CCR5, and CXCR4 ...
Aug 18, 2020
... found on the surface of the virus. In HIV, env encodes the protein gp160, which is cleaved into gp120 and gp41, making up the envelope spike complex that binds to CD4, CCR5, and CXCR4 ...
Aug 18, 2020
CCR5 (chemokine receptor type 5)
(HIV/AIDS Research: Its History & Future Meeting)
... surface of white blood cells. In HIV infection, the HIV virion coat protein gp120 binds to the T cell glycoprotein CD4 and to CCR5, triggering the cell to absorb the HIV ...
Jan 03, 2021
... surface of white blood cells. In HIV infection, the HIV virion coat protein gp120 binds to the T cell glycoprotein CD4 and to CCR5, triggering the cell to absorb the HIV ...
Jan 03, 2021
5.4 Edward Berger — Discovery of HIV Co-receptors
(HIV/AIDS Research: Its History & Future Meeting)
... isolates. (16, 17, 18) Very soon thereafter, several groups showed that the gp120 actually physically binds to the chemokine receptor, to the 00:20:00 coreceptor. (19 ...
Apr 27, 2021
... isolates. (16, 17, 18) Very soon thereafter, several groups showed that the gp120 actually physically binds to the chemokine receptor, to the 00:20:00 coreceptor. (19 ...
Apr 27, 2021
1.7 Max Essex — From Feline Leukemia Virus to AIDS in Africa
(HIV/AIDS Research: Its History & Future Meeting)
... Immunology and Infectious Diseases. One of the first to suspect that AIDS was caused by a retrovirus, and discovered the gp120 protein of HIV in 1984 (see minute 12:00). This talk covers the 1960s ...
Apr 27, 2021
... Immunology and Infectious Diseases. One of the first to suspect that AIDS was caused by a retrovirus, and discovered the gp120 protein of HIV in 1984 (see minute 12:00). This talk covers the 1960s ...
Apr 27, 2021
6.4 Barton Haynes — Development of HIV Vaccine: Steps and Missteps
(HIV/AIDS Research: Its History & Future Meeting)
... sensitive to soluble CD4 and nor were they sensitive to the easy to induce V3 or other gp120 antibodies. That really leads us into the next stage of HIV vaccine development and where ...
Apr 27, 2021
... sensitive to soluble CD4 and nor were they sensitive to the easy to induce V3 or other gp120 antibodies. That really leads us into the next stage of HIV vaccine development and where ...
Apr 27, 2021
5.1 Flossie Wong-Staal — Discovery of Human Retroviral Transactivators
(HIV/AIDS Research: Its History & Future Meeting)
... perspective, I think most of the efforts has been on neutralizing antibodies against gp120, either manmade or naturally occurring in patients. So far I think some ...
Apr 27, 2021
... perspective, I think most of the efforts has been on neutralizing antibodies against gp120, either manmade or naturally occurring in patients. So far I think some ...
Apr 27, 2021
6.2 Dennis Burton — How Does HIV Evade the Antibody Response?
(HIV/AIDS Research: Its History & Future Meeting)
... high mannose sugars here, the CD4 binding site, a region between gp41 and gp120 and close to the membrane, the membrane proximal, external region. I'll just comment on two ...
Apr 27, 2021
... high mannose sugars here, the CD4 binding site, a region between gp41 and gp120 and close to the membrane, the membrane proximal, external region. I'll just comment on two ...
Apr 27, 2021
Session 10: What Have We Learned?
(HIV/AIDS Research: Its History & Future Meeting)
... already know the antibodies don’t last. I know that’s true of all gp120 vaccines. I know that they should all fail unless we solve this problem ...
Apr 27, 2021
... already know the antibodies don’t last. I know that’s true of all gp120 vaccines. I know that they should all fail unless we solve this problem ...
Apr 27, 2021
Session 7: Prospects for an HIV Vaccine
(HIV/AIDS Research: Its History & Future Meeting)
... actually get to the definitive experiments. We've gone from G recombinant proteins, gp120 and the frustration of the vaccine failures, never really dissecting that. That's a very important thing ...
Apr 27, 2021
... actually get to the definitive experiments. We've gone from G recombinant proteins, gp120 and the frustration of the vaccine failures, never really dissecting that. That's a very important thing ...
Apr 27, 2021
1.4 Robin Weiss — Retrovirus History and Early Searches for Human Retroviruses
(HIV/AIDS Research: Its History & Future Meeting)
... virus and of HIV infected patients, and compare them to surface immunofluorescence and a competitive radioimmunoassay for gp120. You can see that both sets of patients with high titers of virus measured ...
Apr 27, 2021
... virus and of HIV infected patients, and compare them to surface immunofluorescence and a competitive radioimmunoassay for gp120. You can see that both sets of patients with high titers of virus measured ...
Apr 27, 2021
6.5 Emilio Emini — Issues in HIV Vaccine Development: Will the Future be any Easier than the Past?
(HIV/AIDS Research: Its History & Future Meeting)
... here. The original RV 140 or the RV 144 observation that was done using ALVAC and gp120, the work that's been done with the adeno 26 vector. This work done with the CMV ...
Apr 27, 2021
... here. The original RV 140 or the RV 144 observation that was done using ALVAC and gp120, the work that's been done with the adeno 26 vector. This work done with the CMV ...
Apr 27, 2021
8.3 George Shaw — Transmitted/Founder HIV Genomes: What They Teach Us
(HIV/AIDS Research: Its History & Future Meeting)
... Joseph Sodroski. “LineageSpecific Differences between Human and Simian Immunodeficiency Virus Regulation of Gp120 Trimer Association and CD4 Binding.” Journal of Virology 86, no. 17 (September 1 ...
Apr 27, 2021
... Joseph Sodroski. “LineageSpecific Differences between Human and Simian Immunodeficiency Virus Regulation of Gp120 Trimer Association and CD4 Binding.” Journal of Virology 86, no. 17 (September 1 ...
Apr 27, 2021