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provirus: a virus genome that is integrated into the DNA of a host cell. Retroviruses like HIV integrate their genomes into their targeted host cells with the help of integrase.

Found 10 search result(s) for provirus OR proviral.

Page: 1.6 Harold Varmus — Animal Retroviruses and Cancer Research (HIV/AIDS Research: Its History & Future Meeting)
... chromosomes. I'm going to tell you a lot about why, in thinking about the provirus hypothesis, it's correct to focus on reverse transcriptase. That is the big enchilada in the provirus world. John Coffin has beautifully told you about its discovery ...
Apr 27, 2021
Page: 8.1 John Mellors — MACS and Beyond: Epidemiology, Viremia and Pathogenesis (HIV/AIDS Research: Its History & Future Meeting)
... specific location, but that was redundant in three locations. Amplified 00:17:00 the fulllength provirus and much to our surprise between the integration sites, the provirus appeared to be intact. Amplified it in two halves, transfected it into permissive cells, and then passed it into CD4positive ...
Apr 27, 2021
Page: 8.4 Robert Siliciano — The Challenge of the HIV Reservoir (HIV/AIDS Research: Its History & Future Meeting)
... resting cells don't produce virus. We could show they contain integrated provirus by an inverse PCR method that amplifies the junction between host DNA and the provirus. And most importantly, we showed that although these cells don't produce a virus, if you ...
Apr 27, 2021
Page: 1.5 John Coffin — The Origin of Molecular Retrovirology (HIV/AIDS Research: Its History & Future Meeting)
... steps in retrovirus replication that characterize retroviruses which are reverse transcription, the formation of the DNA provirus from an RNA template, and the integration step. I will not actually discuss the integration that'll ...
Apr 27, 2021
Page: 5.1 Flossie Wong-Staal — Discovery of Human Retroviral Transactivators (HIV/AIDS Research: Its History & Future Meeting)
... 30 there's some indication that maybe there isn't a reduction of HIV reservoir as measured by proviral DNA. This just shows some of the patients. In a few patients of course, the viral DNA ...
Apr 27, 2021
Page: 3.2 Samuel Broder: The First Clinical Trials of Antiretroviral Drugs (HIV/AIDS Research: Its History & Future Meeting)
... arose at that time. The high rate of viral mutation, fostering drug resistance, or coupled to proviral integration into host DNA, latent viral reservoirs, all of these would work against ...
Apr 27, 2021
Page: 2.6 Tony Fauci — 35 Years of HIV/AIDS: Science and Policy (HIV/AIDS Research: Its History & Future Meeting)
... described, in the blood, that the CD4 T cell that maintained its expression contained the HIV provirus in patients and individuals who had not yet developed fullblown AIDS.  We then went ...
Apr 27, 2021
Page: 5.3 Michael Malim — Discovery of APOBEC Restriction (HIV/AIDS Research: Its History & Future Meeting)
... prevent infection, you really want to stop this thing happening, which is the integration of proviral DNA. Something we've heard about on the 00:19:00 first night ...
Apr 27, 2021
Page: integrase (HIV/AIDS Research: Its History & Future Meeting)
... retroviral integrase (IN): enzyme that integrates a retrovirus' genome into the host cell genome, resulting in a provirus
Aug 19, 2020
Page: endogenous retrovirus (ERV) (HIV/AIDS Research: Its History & Future Meeting)
... endogenous retrovirus (ERV): a DNA sequence derived from a retrovirus (provirus) more or less permanently embedded in the host organism's genome
Aug 19, 2020

 

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