Page tree
Skip to end of metadata
Go to start of metadata

Found 40 search result(s) for "reverse transcription" OR "reverse transcriptase" OR RT.

Page: non-nucleoside reverse-transcriptase inhibitors (NNRTIs) (HIV/AIDS Research: Its History & Future Meeting)
... Nonnucleoside reversetranscriptase inhibitors (NNRTIs) are, as the name suggests, drugs that inhibit the function of viral reverse transcriptase, but not as nucleoside analogues. Instead, NNRTIs target features of reverse transcriptase other than domains responsible for DNA polymerization
Jan 11, 2021
Page: reverse transcriptase assay (HIV/AIDS Research: Its History & Future Meeting)
... Assays to detect reverse transcriptase and distinguish between reverse transcriptases
Aug 24, 2020
Page: nucleosides, nucleotides, nucleoside analogues, nucleoside reverse transcriptase inhibitors (NRTIs), nucs (HIV/AIDS Research: Its History & Future Meeting)
... physiologically functioning like natural guanosine during viral DNA polymerization. A nucleoside reverse transcriptase inhibitor (NRTI) is an antiretroviral drug that inhibits the functioning of reverse transcriptase, which consist of nucleoside analogues that specifically prevent viral reverse transcriptase from functioning ...
Jan 18, 2021
Page: epistemic object becomes the technical object (HIV/AIDS Research: Its History & Future Meeting)
... Press, 1997), to describe the process whereby an original, hypothetical object of inquiry (e.g., reverse transcription, the "epistemic object") becomes clearer, more accepted, and more concrete as it transitions to being ...
Aug 26, 2020
Page: ribonuclease (RNase); RNase H (HIV/AIDS Research: Its History & Future Meeting)
... nearly all living organisms. retroviral RNase H is not a separate protein, but a domain of reverse transcriptase, and performs the critical part of removing the viral RNA template to make room for the second ...
Aug 26, 2020
Page: 1.5 John Coffin — The Origin of Molecular Retrovirology (HIV/AIDS Research: Its History & Future Meeting)
... drugs, we all know that current antiHIV therapy rests primarily on the use of reverse transcriptase inhibitors, not solely but primarily. A triplet is the singlepill regimen is all reverse transcriptase inhibitors. 00:24:00 #epistemic object becomes the technical object #reverse ...
Apr 27, 2021
Page: pol (HIV/AIDS Research: Its History & Future Meeting)
... pol: encodes viral enzymes. In HIV, pol encodes the enzymes reverse transcriptase (RT), integrase (IN), HIV protease (PR), and RNase H
Aug 18, 2020
Page: 8.4 Robert Siliciano — The Challenge of the HIV Reservoir (HIV/AIDS Research: Its History & Future Meeting)
... internal deletions 00:19:36 caused by a copy choice recombination during reverse transcription. (35) Those are shown in white. It's actually hard to find an intact provirus ... ...
Apr 27, 2021
Page: 1.6 Harold Varmus — Animal Retroviruses and Cancer Research (HIV/AIDS Research: Its History & Future Meeting)
... fact that there were deletion mutants that spanned most or all of the gene and that we had reverse transcriptase 00:14:00 in the precloning era to make a radioactive probe with reverse transcriptase that was specific for the region of the Rous sarcoma virus that contain most or all of the src ...
Apr 27, 2021
Page: 5.3 Michael Malim — Discovery of APOBEC Restriction (HIV/AIDS Research: Its History & Future Meeting)
... APOBEC3 proteins could sit on viral RNA and just act as a barrier to the progression of reverse transcriptase, or perhaps you could just modify the activity reverse transcriptase directly. 00:16:00 We're very interested in trying to address these questions ...
Apr 27, 2021
Page: 3.3 Douglas Richman: Antiviral Drug Resistance and Combination ART (HIV/AIDS Research: Its History & Future Meeting)
... late 80s. What we looked at was the appearance of mutations in the target enzyme with this nonnucleoside RT (reverse transcriptase) inhibitor (NNRTI). What we showed is that—we 00:07:00 used ... approach to antiretroviral therapy. #in vitro vs. in vivo #nonnucleoside reversetranscriptase inhibitors (NNRTIs) # ...
Apr 27, 2021
Page: 8.2 David Ho — Unraveling of HIV Dynamics In Vivo (HIV/AIDS Research: Its History & Future Meeting)
... being produced each day, undergoing new rounds of infection, going through reverse transcription 00:18:30 with a rate that is high as Louis Mansky and Howard Temin (1934 ...
Apr 27, 2021
Page: nevirapine (NVP, Viramune) (HIV/AIDS Research: Its History & Future Meeting)
nonnucleoside reversetranscriptase inhibitor (NNRTI), first approved for use in 1996
Jan 08, 2021
Page: dapivirine (DPV) (HIV/AIDS Research: Its History & Future Meeting)
... Dapivirine is a nonnucleoside reverse transcriptase inhibitor, commonly used in the vaginal ring
Feb 04, 2021
Page: 2.5 Françoise Barré-Sinoussi — Discovery of HIV (HIV/AIDS Research: Its History & Future Meeting)
... replication of the reverse transcriptase and LAV, and found 00:25:00 out that, yes, the reverse transcriptase was blocked. So HPA23 was used to treat three patients with AIDS at the end, of course ... involved as a young researcher in retroviruses and cancer. We heard yesterday about the discovery of the  ...
Apr 27, 2021
Page: FTC (emtricitabine, Emtriva, Coviracil) (HIV/AIDS Research: Its History & Future Meeting)
... FTC (emtricitabine), 2',3'dideoxy5fluoro3'thiacytidine, a nucleoside analogue of cytidine and a reverse transcriptase inhibitor. FTC is sold in combination with tenofovir as Truvada to treat HIV
Jan 11, 2021
Page: tenofovir (TDF, Viread) (HIV/AIDS Research: Its History & Future Meeting)
... Tenofovir (tenofovir disproxil, sold as Viread) is a nucleotide reverse transcriptase inhibitor, approved for use in 2001 to treat HIV. A related prodrug is tenofovir alafenamide ...
Jan 18, 2021
Page: AZT (azidothymidine) (HIV/AIDS Research: Its History & Future Meeting)
... first effective antiretroviral to treat AIDS on the market, with much controversy. AZT is a nucleoside reverse transcriptase inhibitor, and is an analogue of thymidine. Combivir is a double combination of AZT and 3TC. Trizivir is a triple ...
Jan 11, 2021
Page: 8.1 John Mellors — MACS and Beyond: Epidemiology, Viremia and Pathogenesis (HIV/AIDS Research: Its History & Future Meeting)
... Mican, Michael Polis, Robin L. Dewar, et al. “New RealTime Reverse TranscriptaseInitiated PCR Assay with SingleCopy Sensitivity for Human Immunodeficiency Virus Type 1 ...
Apr 27, 2021
Page: RNA polymerase, RNA replicase (HIV/AIDS Research: Its History & Future Meeting)
... template. These are essential for the reproduction of most RNA viruses except for retroviruses, which use reverse transcriptase to create a DNA template out of the viral RNA genome
Jan 01, 2021
Page: Dulbecco, Renato (1914–2012) (HIV/AIDS Research: Its History & Future Meeting)
... Nobel Prize in Physiology or Medicine along with Howard Temin and David Baltimore for the discovery of reverse transcriptase
Aug 19, 2020
Page: Temin, Howard M. (1934–1994) (HIV/AIDS Research: Its History & Future Meeting)
... virologist at the University of WisconsinMadison. Awarded the Nobel Prize in Physiology or Medicine in 1975 for the discovery of reverse transcriptase, along with David Baltimore and Renato Dulbecco
Sep 04, 2020
Page: 3.1 Marty St. Clair: Discovery of AZT as the First Anti-HIV Drug (HIV/AIDS Research: Its History & Future Meeting)
... life." I learned how to replicate the virus. I learned how to isolate reverse transcriptase. I learned how to assay reverse transcriptase. All of these things I learned as an undergraduate not realizing 00:04:30 what ...
Apr 27, 2021
Page: 6.5 Emilio Emini — Issues in HIV Vaccine Development: Will the Future be any Easier than the Past? (HIV/AIDS Research: Its History & Future Meeting)
... doing at the same time was working on the development of antiretroviral agents. One of the ones was a nonnucleoside reverse transcriptase inhibitor L697,661, which was never ultimately fully developed, but we did bring ... ...
Apr 27, 2021
Page: retrovirus classification, subfamilies, and genera (HIV/AIDS Research: Its History & Future Meeting)
... Until the discovery of reverse transcriptase in 1970 (see 1.5 John Coffin — The Origin of Molecular Retrovirology), retroviruses were ...
Jan 04, 2021
Page: 6.3 Bruce Walker — Role of T Cells in Controlling HIV Infection (HIV/AIDS Research: Its History & Future Meeting)
... ADCC that we were seeing in these assays using envelope. Bernie had developed a reverse transcriptase expressing vector. 00:09:00 We got that RT expressing vector, and what we saw was terrific specific killing of autologous target ...
Apr 27, 2021
Page: Genes (HIV/AIDS Research: Its History & Future Meeting)
... pol https://libwiki.cshl.edu/confluence/display/AT/pol?src=contextnavpagetreemode, short for "polyprotein": encodes enzymes necessary for viral replication, including reverse transcriptase, protease, and integrase. env, short for "envelope": encodes the proteins found on the outer envelope ... ...
Mar 01, 2021
Page: iconoclasm in science (HIV/AIDS Research: Its History & Future Meeting)
... assumptions that form the heart of many scientific disciplines. In this sense, Temin's "iconoclastic" theory of reverse transcription destroyed the "icon" of the Central Dogma that had been so essential in the early development ...
Aug 26, 2020
Page: 3.5 Daria Hazuda: Discovery and Development of Integrase Inhibitors (HIV/AIDS Research: Its History & Future Meeting)
... Karen A. Kirby, Emily M. Ryan, et al. “Mechanism of Inhibition of HIV1 Reverse Transcriptase by 4′Ethynyl2Fluoro2′Deoxyadenosine Triphosphate, a TranslocationDefective Reverse Transcriptase Inhibitor.” Journal of Biological Chemistry 284, no. 51 (December 18, 2009): 35681 ...
Apr 27, 2021
Page: 3.2 Samuel Broder: The First Clinical Trials of Antiretroviral Drugs (HIV/AIDS Research: Its History & Future Meeting)
... divergent from other forms of HIV, and it too was suppressed by AZT. We found there was a reverse transcriptase inhibition in peripheral blood mononuclear cells (PBMCs). 00:15:00 This was an experiment ... against the possibility of treating this virus effectively. There was a belief by some that the clinical disease cannot be ...
Apr 27, 2021
Page: 8.6 David Baltimore — Bringing it to an End (And Where Are We Going?) (HIV/AIDS Research: Its History & Future Meeting)
... My own involvement in it came accidentally. It was that, 00:01:00 having discovered the reverse transcriptase and therefore been involved in retrovirus research, when HIV was discovered I took ... ...
Apr 27, 2021
Page: 2.4 Robert Gallo — Discoveries of Human Retrovirus, Their Linkage to Disease as Causative Agents & Preparation for the Future (HIV/AIDS Research: Its History & Future Meeting)
... health ReadConnole, Elizabeth https://libwiki.cshl.edu/confluence/display/AT/ReadConnole%2CElizabeth  Reitz, Marvin S. https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=15532340  rev https://libwiki.cshl.edu/confluence/display/AT/rev  reverse transcriptase https://libwiki.cshl.edu/confluence/display/AT/reversetranscriptase  reverse transcriptase assay https://libwiki.cshl.edu/confluence/display/AT/reversetranscriptaseassay  rex https://libwiki.cshl.edu/confluence/display/AT/rex  Safai, Bijan https://libwiki.cshl.edu/confluence/display/AT/Safai%2CBijan  San Francisco, California ... ...
Apr 27, 2021
Page: 3.4 Raymond Schinazi — Discovery and Development of Novel NRTIs (HIV/AIDS Research: Its History & Future Meeting)
... Eddy Arnold: I have a question. Polymerases are just fantastic targets, of course, reverse transcriptase is the central drug target for HIV, but sofosbuvir it's such a knockitoutofthepark drug. Given the incredibly ...
Apr 27, 2021
Page: 1.4 Robin Weiss — Retrovirus History and Early Searches for Human Retroviruses (HIV/AIDS Research: Its History & Future Meeting)
... Lionel and Elizabeth Crawford. Then came the age of oncogenes, 00:05:30 the discover with reverse transcriptase, and then the human retroviruses. Robin A. Weiss, b. 1940, Prof. of Viral Oncology at University ...
Apr 27, 2021
Page: 2.3 Mark Harrington — The Importance of Activism to the US Response (HIV/AIDS Research: Its History & Future Meeting)
... Health (NIH) https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12944131  New York https://libwiki.cshl.edu/confluence/display/AT/NewYork  nucleosides, nucleoside analogues, nucleoside reverse transcriptase inhibitors (NRTIs), nucs https://libwiki.cshl.edu/confluence/display/AT/nucleosides%2Cnucleosideanalogues%2Cnucleosidereversetranscriptaseinhibitors%28NRTIs%29%2Cnucs  Obama, Barack (b. 1961) https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=15532281  Pantaleo ... ...
Apr 27, 2021
Page: 3.6 John C. Martin — Making it Simpler: A Single Pill to Treat HIV (HIV/AIDS Research: Its History & Future Meeting)
... C. Cundy. “Selective Intracellular Activation of a Novel Prodrug of the Human Immunodeficiency Virus Reverse Transcriptase Inhibitor Tenofovir Leads to Preferential Distribution and Accumulation in Lymphatic Tissue.” Antimicrobial Agents ...
Apr 27, 2021
Page: 6.1 Sharon Hillier — Development and Application of Pre-exposure Prophylaxis (PrEP) (HIV/AIDS Research: Its History & Future Meeting)
... developed this ring which slowly releases the ARV (antiretroviral) drug dapivirine as a nonnucleoside reverse transcriptase inhibitor (NNRTI). The entire dose over an entire month of use is 4mg, contrast ...
Apr 27, 2021
Page: 5.1 Flossie Wong-Staal — Discovery of Human Retroviral Transactivators (HIV/AIDS Research: Its History & Future Meeting)
... looked at functional cDNA clones (DNA artificially synthesized from RNA using reverse transcriptase) and looked at the ability to transactivate the LTRlinked CAT genes. (9) I should mention ... ...
Apr 27, 2021
Page: 4.3 Beatrice Hahn — Apes to Humans: The Origin of HIV (HIV/AIDS Research: Its History & Future Meeting)
... Pusey, Anne E. https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=15533704  Ratner, Lee https://libwiki.cshl.edu/confluence/display/AT/Ratner%2CLee  restriction factor https://libwiki.cshl.edu/confluence/display/AT/restrictionfactor  reverse transcriptase https://libwiki.cshl.edu/confluence/display/AT/reversetranscriptase  RNAlater https://libwiki.cshl.edu/confluence/display/AT/RNAlater  Royal Society https://libwiki.cshl.edu/confluence/display/AT/RoyalSociety  Santiago, Mario L. https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=15533645 ... ...
Apr 27, 2021
Page: 8.5 Sharon Lewin — Research to a Cure: A Possible Goal? (HIV/AIDS Research: Its History & Future Meeting)
... lymphoid tissues such as CCL 19 and CCL 21, did actually facilitate the entry of the reverse transcriptase complex and allow for efficient integration. (20, 21, 22, 23) Similarly, if you ... ...
Apr 27, 2021

 

 

 

  • No labels