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T cell (also T-cell). This term indexes T cells in general, as well as CD4+ cells (helper T or Th cells) and CD8+ cells (known as cytotoxic T cell, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, or killer T cell).

HIV causes AIDS primarily by infecting and killing CD4+ helper T cells. The progress of HIV/AIDS infection and remission can be assessed by measuring the CD4+/CD8+ ratio.

This term also indexes the CD4 and CD8 membrane proteins.

Found 63 search result(s) for T cell OR T-cell OR CD4 OR CD8.

Page: 6.3 Bruce Walker — Role of T Cells in Controlling HIV Infection (HIV/AIDS Research: Its History & Future Meeting)
... functional cure is possible. Limited antigen exposure and acute infection enhances T cell functionality. 00:26:00 HIVspecific CD4 and CD8 T cells are likely to be critical to a functional cure, and are likely, through T follicular helper cells ...
Apr 27, 2021
Page: CD4+/CD8+ ratio (HIV/AIDS Research: Its History & Future Meeting)
... CD4/CD8 ratio is the ratio of T helper cells (with the surface marker CD4) to cytotoxic T cells (with the surface marker CD8). Measurement of this ratio was a key clue in discovering the etiology of AIDS
Aug 21, 2020
Page: 5.4 Edward Berger — Discovery of HIV Co-receptors (HIV/AIDS Research: Its History & Future Meeting)
... question. I was wondering, in your initial discovery of the CXR4, have you tried a CD4 T cell cDNA library, before you using HeLa cell? Ed: No. There was no reason to go with a T cell library because we and others had shown ...
Apr 27, 2021
Page: 8.5 Sharon Lewin — Research to a Cure: A Possible Goal? (HIV/AIDS Research: Its History & Future Meeting)
... each administration. Similarly, you see very impressive spikes in CD69 expression on CD4 and CD8 T cells, 00:27:00 which returns rapidly down to basal levels. What's ... Haddad, Laurence De Leval, Cecilia Graziosi, and Giuseppe Pantaleo. “Follicular Helper T ...
Apr 27, 2021
Page: 8.2 David Ho — Unraveling of HIV Dynamics In Vivo (HIV/AIDS Research: Its History & Future Meeting)
... show that there's a 6 to 10 fold increase in 00:29:00 not only CD4 T cell turnover, but CD8 T cell turnover in SIV infection or HIV infection, and that this process had to be halted as soon as possible ... ...
Apr 27, 2021
Page: 6.4 Barton Haynes — Development of HIV Vaccine: Steps and Missteps (HIV/AIDS Research: Its History & Future Meeting)
... trials, two Merck trials of recombinant Ad5 vaccine which was primarily to induce CD8 T cells failed in Phambili in South Africa and in the United States. Then in 2013, the VRC vaccine which ... didn't? (23) The broad neutralizers made plasma autoantibodies had high levels of ...
Apr 27, 2021
Page: 5.1 Flossie Wong-Staal — Discovery of Human Retroviral Transactivators (HIV/AIDS Research: Its History & Future Meeting)
... we see increase in CD8 T cell population, and by the way, there's no decrease in CD4 so that removes the concern about using a CD4 antibody to some degree. It also increased in 00:31:00 HIV antigenspecific ... ...
Apr 27, 2021
Page: 8.1 John Mellors — MACS and Beyond: Epidemiology, Viremia and Pathogenesis (HIV/AIDS Research: Its History & Future Meeting)
... Spindler, Junko Hattori, Elizabeth M. Anderson, et al. “Clonally Expanded CD4 T Cells Can Produce Infectious HIV1 in Vivo.” PNAS 113, no. 7 (February 16 ... Rodríguez et al. was that a CD4 ...
Apr 27, 2021
Page: HTLV (human T-lymphotropic virus) (HIV/AIDS Research: Its History & Future Meeting)
HTLV (human Tlymphotropic virus), known earlier as human Tcell lymphoma virus. HTLVI and HTLVII are discussed in the conference. HTLVIII was another name for HIV until 1986; see discovery and naming of HIV/HTLVIII/LAV/ARV The HTLVI was discovered by Bob ...
Jan 26, 2021
Page: H9 (HuT 78) cell line (HIV/AIDS Research: Its History & Future Meeting)
... H9 cell line is a human T lymphocyte cell line derived from cells from a 53 year old Caucasian lymphoma patient. H9 is a clonal derivative ...
Feb 16, 2021
Page: 2.4 Robert Gallo — Discoveries of Human Retrovirus, Their Linkage to Disease as Causative Agents & Preparation for the Future (HIV/AIDS Research: Its History & Future Meeting)
... cause: the first scientific contribution I think is the clinicians and the people who described CD4 cells as declining, that gave us the hint that things might be in CD4 T cells. Then there was the epidemiology data, principally from CDC and the town crier, Jim Curran, going ...
Apr 27, 2021
Page: HuT-102 cell line (HIV/AIDS Research: Its History & Future Meeting)
... HuT102 cell line is an immortalized line of cutaneous T lymphocytes, derived from cells taken from a 26 year old Black male lymphoma patient
Feb 15, 2021
Page: 8.3 George Shaw — Transmitted/Founder HIV Genomes: What They Teach Us (HIV/AIDS Research: Its History & Future Meeting)
... three.  But the key experiment is this, and this is my last slide. If we now take rhesus CD4 T cells, infect them with SIV, the question is can a productive infection of the target cell express naturally the 5' leader peptides from a natural infection, and can ...
Apr 27, 2021
Page: 8.4 Robert Siliciano — The Challenge of the HIV Reservoir (HIV/AIDS Research: Its History & Future Meeting)
... Karen Chadwick, Theodore Pierson, Kendall Smith, et al. “Latent Infection of CD4 T Cells Provides a Mechanism for Lifelong Persistence of HIV1, Even in Patients on Effective Combination Therapy ... like this. (4) They viewed latency in the context of the normal physiology of 00:02:00 CD4 ...
Apr 27, 2021
Page: 1.7 Max Essex — From Feline Leukemia Virus to AIDS in Africa (HIV/AIDS Research: Its History & Future Meeting)
... END OF VIDEO   #Botswana Combination Prevention Project (BCPP)       #prevention of HIV/AIDS #CD4/CD8 ratio   #phylogenetic viral linkage analysis (phylogenetic network analysis) Citations 1 ... Some of the things we were involved in was actually published later in 1984 based on the  ...
Apr 27, 2021
Page: 2.1 Paul Volberding — The First Patients (HIV/AIDS Research: Its History & Future Meeting)
... asked me to work up these patients 00:26:30 and they had no OKT4 cells (Thelper/CD4 cells), as we called them then, lots of OKT8 cells (cytotoxic T/CD8/killer T cells ...
Apr 27, 2021
Page: 5.5 Andrew Rice — Mechanism of tat Transactivation (HIV/AIDS Research: Its History & Future Meeting)
... kinase PTEFb, we had reagents. In this paper, with Kathy's lab, we looked at CD4 T cells in monocytes, macrophages, at the regulation of this kinase and we found that it is downregulated in CD4 lymphocytes in resting cells (11). This is now relevant to the current HIV cure efforts ...
Apr 27, 2021
Page: CCR5 (chemokine receptor type 5) (HIV/AIDS Research: Its History & Future Meeting)
... CCR5 is a receptor protein on the surface of white blood cells. In HIV infection, the HIV virion coat protein gp120 binds to the T cell glycoprotein CD4 and to CCR5, triggering the cell to absorb the HIV virion and thus becoming infected
Jan 03, 2021
Page: 6.5 Emilio Emini — Issues in HIV Vaccine Development: Will the Future be any Easier than the Past? (HIV/AIDS Research: Its History & Future Meeting)
... 14:30 controls. What we got here on the lefthand panel here, these are the CD4 T cell counts subsequent to challenge and here is the viremia on the right. Of course, every line, there's ... potential of vaccines that would elicit 00:12:30 cellular immune responses or ...
Apr 27, 2021
Page: 2.6 Tony Fauci — 35 Years of HIV/AIDS: Science and Policy (HIV/AIDS Research: Its History & Future Meeting)
... moved to T cells and were starting studying the phenotypic abnormalities, as well as the depletion of T cells. (18, 19, 20) In 1989, we described, in the blood, that the CD4 T cell that maintained its expression contained the HIV provirus in patients and individuals who ...
Apr 27, 2021
Page: 1.4 Robin Weiss — Retrovirus History and Early Searches for Human Retroviruses (HIV/AIDS Research: Its History & Future Meeting)
... 00 or not. (16) Incidentally, it's not really clear that HTLVII is a pathogen, but it does immortalize CD4 cells in vitro, it has transforming properties, and it's prevalent in the West Indies, because the African ... put in, so it was a way of titrating them, as well as a way of examining what's going on in ...
Apr 27, 2021
Page: CCR5 receptor antagonist (HIV/AIDS Research: Its History & Future Meeting)
... antagonists are drugs that block the CCR5 receptor, which HIV uses to gain entry into CD4 T cells
Mar 07, 2021
Page: 1.6 Harold Varmus — Animal Retroviruses and Cancer Research (HIV/AIDS Research: Its History & Future Meeting)
... Mellors' point— Harold: Or EBV. John Coffin: —I would argue about CD4 T cell tumors and AIDS patients. I would argue that malignant CD4 cells or premalignant cells are probably excellent targets for the HIV that's already present ...
Apr 27, 2021
Page: 2.5 Françoise Barré-Sinoussi — Discovery of HIV (HIV/AIDS Research: Its History & Future Meeting)
... isolate the virus. (7) We showed with David that virus had a selective tropism for CD4 T cells, and we also reported in December issue of Nature 1984, as did Robin Weiss ... idea at that 00:17:30 time, that was probably why the patients were losing their CD4 ...
Apr 27, 2021
Page: 8.6 David Baltimore — Bringing it to an End (And Where Are We Going?) (HIV/AIDS Research: Its History & Future Meeting)
... T cells? Well, in the cancer field, we're engineering 00:21:30 T cells all the time now. What we do is put in, for instance, a T cell receptor gene, or a CAR (chimeric antigen receptor), which are generally more ...
Apr 27, 2021
Page: Session 7: Prospects for an HIV Vaccine (HIV/AIDS Research: Its History & Future Meeting)
... actually the public sector got involved. We then moved including me, into the belief that CD8 T cells in control of viremia would be an easier target for HIV vaccines. It turns out that actually ... virology, innate immunity, adaptive immune phenotypes. We looked at the specific question of ...
Apr 27, 2021
Page: 5.3 Michael Malim — Discovery of APOBEC Restriction (HIV/AIDS Research: Its History & Future Meeting)
... monkey, the Vif protein works very well in cognate African green monkey cells, and it is nonfunctional in human T cells. Taking all that together, we thought that we knew that Vif worked in cells ... ...
Apr 27, 2021
Page: 2.0 Michael Gottlieb — Introduction to Session 2 (HIV/AIDS Research: Its History & Future Meeting)
... we saw were associated with immunosuppression 00:02:00 and the near absence of CD4 cells. You can see on the bottom panel of an original Kodachrome slide. The near absence ...
Apr 27, 2021
Page: 2.3 Mark Harrington — The Importance of Activism to the US Response (HIV/AIDS Research: Its History & Future Meeting)
... surrogate markers, even what turned out to be shitty surrogate markers like CD4 cells and changes in CD4 cells from single nuc nucleoside regimens; and to do the parallel track, which was a huge ... ...
Apr 27, 2021
Page: lymphocyte (HIV/AIDS Research: Its History & Future Meeting)
... One of the types of white blood cells. Includes T cells, B cells, and natural killer cells. In this index T cells and B cells are not indexed as children
Aug 23, 2020
Page: 6.2 Dennis Burton — How Does HIV Evade the Antibody Response? (HIV/AIDS Research: Its History & Future Meeting)
... Sharon Reddy, Elizabeth W. Mackey, et al. “PD1 Expression on HIVSpecific T Cells Is Associated with TCell Exhaustion and Disease Progression.” Nature 443, no. 7109 (September 21 ... John Mascola and colleagues. And this antibody is—what they do is they 00:20:30 imitate ...
Apr 27, 2021
Page: blood — banks, donors, plasma, screening, transfusions, clotting factors (factor VIII), PBMCs (HIV/AIDS Research: Its History & Future Meeting)
... any peripheral blood cell that has a single cell nucleus, i.e. lymphocytes (T cells, B cells, NK cells) and monocytes; thus PBMC excludes platelets and red blood cells, which have no cell ...
Jan 11, 2021
Page: 3.2 Samuel Broder: The First Clinical Trials of Antiretroviral Drugs (HIV/AIDS Research: Its History & Future Meeting)
... 00 this was a phase 1 study in cancer patients, but the point still will hold—total T cell counts fell during all treatment courses, with the mean absolute Tcell count ... also found that it penetrated the CNS (central nervous system), which was all good. # ...
Apr 27, 2021
Page: 2.2 James Curran — Deciphering the Epidemiology of AIDS (HIV/AIDS Research: Its History & Future Meeting)
... Disease as Causative Agents & Preparation for the Future https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12943622 6.3 Bruce Walker — Role of T Cells in Controlling HIV Infection https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12943557 12th International AIDS Conference, Geneva, 1998 ... ...
Apr 27, 2021
Page: interleukins (HIV/AIDS Research: Its History & Future Meeting)
... interleukins are a diverse family of signaling proteins secreted primarily by white blood cells. Interleukin 2 stiumlates the growth of T cells, and was discovered by Bob Gallo and others in 1976–77
Jan 01, 2021
Page: Doherty, Peter C. (b. 1940) (HIV/AIDS Research: Its History & Future Meeting)
... Immunologist and Nobel Laureate (1996) for the discovery of how T cells recognize antigens
Feb 26, 2021
Page: 4.3 Beatrice Hahn — Apes to Humans: The Origin of HIV (HIV/AIDS Research: Its History & Future Meeting)
... when we checked, after he was transferred to Chimp Haven, he had a CD4 T cell count of less than 300 and when we talked to the vets and told them ... ...
Apr 27, 2021
Page: 1.5 John Coffin — The Origin of Molecular Retrovirology (HIV/AIDS Research: Its History & Future Meeting)
... Ruprecht — Session 4, Introduction 2 https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12943514 6.3 Bruce Walker — Role of T Cells in Controlling HIV Infection https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12943557 8.6 David Baltimore — Bringing it to an End (And Where ... cells ...
Apr 27, 2021
Page: Session 6: Immunology and Prevention (HIV/AIDS Research: Its History & Future Meeting)
... Does HIV Evade the Antibody Response? https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12943555&src=contextnavpagetreemode 6.3 Bruce Walker — Role of T Cells in Controlling HIV Infection https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12943557&src=contextnavpagetreemode 6.4 Barton Haynes — Development of HIV Vaccine ...
Apr 27, 2021
Page: CAT assay (chloramphenicol acetyltransferase) (HIV/AIDS Research: Its History & Future Meeting)
... Rosen, and William A. Haseltine, “TransActing Transcriptional Activation of the Long Terminal Repeat of Human T Lymphotropic Viruses in Infected Cells,” Science 225, no. 4660 (July 27, 1984): 381–85, doi:10.1126 ...
Mar 07, 2021
Page: phytohaemagglutinin (PHA) (HIV/AIDS Research: Its History & Future Meeting)
... Phytohaemagglutinin (PHA) is a legume protein. It is known for its ability to trigger T cell division, among other things
Jan 07, 2021
Page: Concanavalin A (ConA) (HIV/AIDS Research: Its History & Future Meeting)
... Concanavalin A (ConA) is a legume protein that is known for stimulating the production of T cells in mouse models
Jan 07, 2021
Page: Females Rising through Education, Support, and Health (FRESH) (HIV/AIDS Research: Its History & Future Meeting)
... Program run through the Ragon Institute, see 6.3 Bruce Walker — Role of T Cells in Controlling HIV Infection
Feb 12, 2021
Page: 3.1 Marty St. Clair: Discovery of AZT as the First Anti-HIV Drug (HIV/AIDS Research: Its History & Future Meeting)
... First Clinical Trials of Antiretroviral Drugs https://libwiki.cshl.edu/confluence/display/AT/3.2SamuelBroder%3ATheFirstClinicalTrialsofAntiretroviralDrugs 6.3 Bruce Walker — Role of T Cells in Controlling HIV Infection https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12943557  6.6 Robert Redfield — The PEPFAR Program to Treat ... what a petri dish is anymore. 00:12:00 If you have your cell ...
Apr 27, 2021
Page: RANTES (HIV/AIDS Research: Its History & Future Meeting)
... RANTES (regulated on activation, normal T cell expressed and secreted), also known as Chemokine (CC motif) ligand 5, is a human ...
Jan 29, 2021
Page: 9.1 Jon Cohen — Responding to AIDS: A Journalist's View (HIV/AIDS Research: Its History & Future Meeting)
... Disease as Causative Agents & Preparation for the Future https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12943622 6.3 Bruce Walker — Role of T Cells in Controlling HIV Infection https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12943557 8.2 David Ho — Unraveling of HIV Dynamics ... ...
Apr 27, 2021
Page: 1.1 James D. Watson — Welcome (HIV/AIDS Research: Its History & Future Meeting)
... why does something work on both DNA and RNA viruses are not against animal cells? Most of you don't know the interior cells have no SS bonds. At least in the short time, you can go after ...
Apr 27, 2021
Page: 6.7 Salim Abdool Karim — Stopping the Spread of HIV in Developing Countries (HIV/AIDS Research: Its History & Future Meeting)
... Development and Application of Preexposure Prophylaxis (PrEP) https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12943553 6.3 Bruce Walker — Role of T Cells in Controlling HIV Infection https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12943557 18th International AIDS Conference, Vienna, 2010 ... ...
Apr 27, 2021
Page: discovery and naming of HIV/HTLV-III/LAV/ARV (HIV/AIDS Research: Its History & Future Meeting)
Because HIV was independently discovered by three different scientific groups in 1983–1984, three different names for HIV entered circulation: LAV, or lymphadenopathy associated virus, was the name used by the group led by Françoise BarréSinoussi and Luc Montagnier at the Pasteur Institute ...
Mar 07, 2021
Page: 4.1 Ronald Desrosiers — The Origin of SIVmac: Non-human Primate Models for HIV (HIV/AIDS Research: Its History & Future Meeting)
... including the incorporation of micro RNA target sequences that shut off expression and antigenpresenting cells like dendritic cells 00:30:00 and use of AAV8, it looks like at least with the 406 antibody ... ...
Apr 27, 2021
Page: 3.4 Raymond Schinazi — Discovery and Development of Novel NRTIs (HIV/AIDS Research: Its History & Future Meeting)
... minus enantiomer was not toxic. Actually, it was very interesting. The plus is toxic, especially in CM cells (memory T cells), but not many other cells. Bone marrow toxicity 00:14:30 was quite high with the plus enantiomer ... ...
Apr 27, 2021
Page: 9.2 Staffan Hildebrand — Face of AIDS Project (HIV/AIDS Research: Its History & Future Meeting)
... 30 but unintelligible 00:14:31 given me to try a transmission to more cells or cold blood again or to another cell line and then unintelligible 00:14:37— Bob Gallo: We think the macrophage ...
Apr 27, 2021
Page: 5.6 Michael Emerman — Host-virus Co-evolution (HIV/AIDS Research: Its History & Future Meeting)
... I had gone native because when we published the rev paper in cell, one of the reviewers suggest that we have a native English speaker correct the paper ...
Apr 27, 2021
Page: Session 10: What Have We Learned? (HIV/AIDS Research: Its History & Future Meeting)
... I don’t understand. Because when you start playing around with activating T cells and it goes wider than the cell that you’re after I think we know from monkeys, we get ... ...
Apr 27, 2021
Page: 3.5 Daria Hazuda: Discovery and Development of Integrase Inhibitors (HIV/AIDS Research: Its History & Future Meeting)
... jbc.272.29.18161 https://doi.org/10.1074/jbc.272.29.18161. Cheng, Alan C., Ryan G. Coleman, Kathleen T. Smyth, Qing Cao, Patricia Soulard, Daniel R. Caffrey, Anna C ...
Apr 27, 2021
Page: 4.2 Martine Peeters — On the Road to HIV: Primate Lentiviruses (HIV/AIDS Research: Its History & Future Meeting)
... Michael Emerman. “Gene Loss and Adaptation to Hominids Underlie the Ancient Origin of HIV1.” Cell Host & Microbe 14, no. 1 (July 17, 2013): 85–92. doi ...
Apr 27, 2021
Page: 6.6 Robert Redfield — The PEPFAR Program to Treat HIV in Africa (HIV/AIDS Research: Its History & Future Meeting)
... Simpler: A Single Pill to Treat HIV https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12943505 6.3 Bruce Walker — Role of T Cells in Controlling HIV Infection https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12943557 Afghanistan https://libwiki.cshl.edu/confluence/display/AT/Afghanistan Africa, subSaharan Africa https://libwiki.cshl.edu/confluence/display/AT/Africa%2CsubSaharanAfrica ...
Apr 27, 2021
Page: retrovirus classification, subfamilies, and genera (HIV/AIDS Research: Its History & Future Meeting)
Until the discovery of reverse transcriptase in 1970 (see 1.5 John Coffin — The Origin of Molecular Retrovirology), retroviruses were often referred to as Ctype viruses, oncoviruses, oncornaviruses (oncoRNA), or RNA tumor viruses. As of 2018 the family of retroviruses is categorized into two subfamilies ...
Jan 04, 2021
Page: 4.4 Michael Worobey — Spread of HIV in the New World (HIV/AIDS Research: Its History & Future Meeting)
... 1789–96. doi:10.1126/science.288.5472.1789 https://doi.org/10.1126/science.288.5472.1789. Zhu, Tuofu, Bette T. Korber, Andre J. Nahmias, Edward Hooper, Paul M. Sharp, and David ...
Apr 27, 2021
Page: 6.1 Sharon Hillier — Development and Application of Pre-exposure Prophylaxis (PrEP) (HIV/AIDS Research: Its History & Future Meeting)
... 2010): 2587–99. doi:10.1056/NEJMoa1011205 https://doi.org/10.1056/NEJMoa1011205. McCormack, Sheena, David T. Dunn, Monica Desai, David I. Dolling, Mitzy Gafos, Richard Gilson ...
Apr 27, 2021

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