The Wnt gene family encodes an evolutionarily conserved set of signal transduction proteins.
The name Wnt arose from the history of the discovery that these genes are found across all animals. It was originally known as the Wingless (Wg) gene in Drosophila genetics, and known to be involved in establishing the body axis in embryogenesis. In 1982 Roel Nusse and Harold Varmus discovered a proto-oncogene in mice that they named int1 ("integration site 1") when exploring the oncogenic properties of mouse mammary tumor virus. Subsequent research revealed that int1 was also involved in establishing the body axis in mouse embryogenesis, and that int1 was, in fact, the same as Wg. The revised name Wnt stands for "Wingless-related integration site."
Found 2 search result(s) for Wnt.
AXIN
(HIV/AIDS Research: Its History & Future Meeting)
... AXIN1 is a gene that encodes Axin1, a protein involved in the regulation of Wnt and βcatenin, and thus a protooncogene
Aug 27, 2020
... AXIN1 is a gene that encodes Axin1, a protein involved in the regulation of Wnt and βcatenin, and thus a protooncogene
Aug 27, 2020
1.6 Harold Varmus — Animal Retroviruses and Cancer Research
(HIV/AIDS Research: Its History & Future Meeting)
... now call Wnt1. (5) #radionuclide, radiolabeling, radioactive tracer That was the way in which the Wnt signaling pathway was discovered. A lot of studies on Wnt gene evolution, Wnt signaling, the world of Wnt and development, and regulation of 00:22:00 stem cell replication
Apr 27, 2021
... now call Wnt1. (5) #radionuclide, radiolabeling, radioactive tracer That was the way in which the Wnt signaling pathway was discovered. A lot of studies on Wnt gene evolution, Wnt signaling, the world of Wnt and development, and regulation of 00:22:00 stem cell replication
Apr 27, 2021