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AZT, azidothymidine, also known as Zidovudine (ZDV). The first effective antiretroviral to treat AIDS on the market, with much controversy. AZT is a nucleoside reverse transcriptase inhibitor, and is an analogue of thymidine.

Combivir is a double combination of AZT and 3TCTrizivir is a triple combination of AZT, 3TC, and abacavir.

 

Found 22 search result(s) for AZT OR ZDV.

Page: 3.1 Marty St. Clair: Discovery of AZT as the First Anti-HIV Drug (HIV/AIDS Research: Its History & Future Meeting)
... patents and intellectual property (IP) 00:15:30 so our patent for AZT was the use of AZT against HIV/AIDS. Anybody can use AZT for any other disease area and not violate our patent. Our patent was specifically ...
Apr 27, 2021
Page: 3.2 Samuel Broder: The First Clinical Trials of Antiretroviral Drugs (HIV/AIDS Research: Its History & Future Meeting)
... come out that way—the rest of the world was asking me, "Why are you saying AZT works?" I was watching results like this, and that is why I knew that AZT was working. What we thought we learned from AZT was it's an active agent ...
Apr 27, 2021
Page: Science (journal) (HIV/AIDS Research: Its History & Future Meeting)
... Françoise BarréSinoussi — Discovery of HIV https://libwiki.cshl.edu/confluence/pages/viewpage.action?pageId=12943624 3.1 Marty St. Clair: Discovery of AZT as the First AntiHIV Drug https://libwiki.cshl.edu/confluence/display/AT/3.1MartySt.Clair%3ADiscoveryofAZTastheFirstAntiHIVDrug 3.4 Raymond Schinazi — Discovery and Development of Novel ...
Mar 06, 2021
Page: 3.3 Douglas Richman: Antiviral Drug Resistance and Combination ART (HIV/AIDS Research: Its History & Future Meeting)
... evaluation of indinavir (IDV, Crixivan, a protease inhibitor) compared to what was then the standard of practice, AZT and 3TC. What was observed is AZT did what you've already seen, AZT 00:19:00 and 3TC, rapid activity and then rapid loss of the activity with the emergence ...
Apr 27, 2021
Page: 3.4 Raymond Schinazi — Discovery and Development of Novel NRTIs (HIV/AIDS Research: Its History & Future Meeting)
... protocol It's not the greatest drug in the world, but it served its purpose, the same way as AZT served its purpose at the time. It was a thymidine kinasedependent drug like AZT. At the time, that was an important drug when it first came out, and many combination studies ...
Apr 27, 2021
Page: Ostertag, Wolfram (1937–2010) (HIV/AIDS Research: Its History & Future Meeting)
... German geneticist, who had possibly used AZT on murine leukemia virus (MLV) in the 1970s
Jan 06, 2021
Page: abacavir (ABC, Ziagen) (HIV/AIDS Research: Its History & Future Meeting)
... 3TC (lamivudine) it is sold as Epzicom in the US, and Kivexa outside the US. In combination with 3TC and AZT it is sold as Trizivir. In combination with 3TC and DTG (dolutegravir) it is sold as Triumeq
Jan 11, 2021
Page: Tools, materials, proteins, drugs, and treatments (HIV/AIDS Research: Its History & Future Meeting)
... Tat, Vif, Vpr, Vpu, Vpx. HIV drugs are categorized by type; e.g., AZT is listed under "nucleosides." Prodrugs (drugs that are reformulated to alter their bioavailability) are listed under ...
Feb 03, 2021
Page: ACTG trial 076 (1991–1994) (HIV/AIDS Research: Its History & Future Meeting)
... Trials Group (ACTG) trial 076, 1991–1994. Test of prophylactic use of AZT (azidothymidine) for pregnant HIVpositive women to prevent mothertochild transmission of HIV. See https://aidsinfo.nih.gov/news/101/actg076questionsandanswers ...
Aug 28, 2020
Page: 2.3 Mark Harrington — The Importance of Activism to the US Response (HIV/AIDS Research: Its History & Future Meeting)
... came through in '92, it was shown that ddI had a clinical benefit over longterm AZT and people who'd already been on the AZT for a while. We dodged a bullet there. Then leading to parallel track was—You know, demos ...
Apr 27, 2021
Page: 9.3 Victoria Harden — The Future of the History of AIDS (HIV/AIDS Research: Its History & Future Meeting)
... Epstein Impure Science. (15) It was published 00:10:30 in 1992. At the time, AZT toxicity was being assailed, and before any effective therapy had been developed ...
Apr 27, 2021
Page: 2.1 Paul Volberding — The First Patients (HIV/AIDS Research: Its History & Future Meeting)
... aggressively by both sides, both 00:19:30 by people that wanted the hope that AZT offered and didn't want placebo and people that didn't want AZT because it was considered to be a toxic drug.   There's a lot to say about activism. We'll ...
Apr 27, 2021
Page: 3.6 John C. Martin — Making it Simpler: A Single Pill to Treat HIV (HIV/AIDS Research: Its History & Future Meeting)
... drug in 2001. We've also done head to head naive studies against AZT and d4T and that's how TDF became the backbone of therapy because it has a better ...
Apr 27, 2021
Page: 8.2 David Ho — Unraveling of HIV Dynamics In Vivo (HIV/AIDS Research: Its History & Future Meeting)
... inhibitors. Then at a conference in 1993, and for the clinical investigators in the audience, you would know that that was the year of AZT & 3TC combination. Charles Boucher from the Netherlands 00:06:30 showed ...
Apr 27, 2021
Page: 2.2 James Curran — Deciphering the Epidemiology of AIDS (HIV/AIDS Research: Its History & Future Meeting)
... have thought of viral loads, my God, and a retroviral drug can be effective? AZT seemed to be a miracle, a discarded cancer drug from the 1970s. Then a very courageous epidemic ...
Apr 27, 2021
Page: 9.1 Jon Cohen — Responding to AIDS: A Journalist's View (HIV/AIDS Research: Its History & Future Meeting)
... He did have troubles later because of these studies. 00:08:00  AZT comes out, approved in March of 1987. (13) That's Robert Schooley, Chip ...
Apr 27, 2021
Page: 2.6 Tony Fauci — 35 Years of HIV/AIDS: Science and Policy (HIV/AIDS Research: Its History & Future Meeting)
... 20:00 were the first to do what Bob had emphasized regarding AZT. Then came the iconic study in the New England Journal of Medicine with Margaret Fischl as the first ...
Apr 27, 2021
Page: 2.4 Robert Gallo — Discoveries of Human Retrovirus, Their Linkage to Disease as Causative Agents & Preparation for the Future (HIV/AIDS Research: Its History & Future Meeting)
... perfect, but it really was the straw that broke the camel's back. That's the historic paper, it's AZT, no matter what you think of AZT. (19) I won't get into the neutralizing antibodies because it's going to be a subject ...
Apr 27, 2021
Page: Session 7: Prospects for an HIV Vaccine (HIV/AIDS Research: Its History & Future Meeting)
... women in Brooklyn, from 00:21:00 the MSM advocates, who felt that AZT was poison. It actually was the effective way to do it, and we got the 076 trial done ...
Apr 27, 2021
Page: 1.7 Max Essex — From Feline Leukemia Virus to AIDS in Africa (HIV/AIDS Research: Its History & Future Meeting)
... we were not involved on—it was done in the US and Europe—to show that 00:19:00 AZT (azidothymidine) could reduce mothertochild transmission, at least from in utero of birth transmissions ...
Apr 27, 2021
Page: 2.5 Françoise Barré-Sinoussi — Discovery of HIV (HIV/AIDS Research: Its History & Future Meeting)
... drug was not working at all. laughter However, we had to wait, the data of course with AZT, 00:25:30 in particular with this publications that I mentioned from Sam Broder ...
Apr 27, 2021
Page: 8.5 Sharon Lewin — Research to a Cure: A Possible Goal? (HIV/AIDS Research: Its History & Future Meeting)
... infected macrophages and one of the first investigators to show that drug resistance could develop to AZT. 00:05:30 I did my PhD after my fellowship ...
Apr 27, 2021

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