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Aciclovir (ACV, or acyclovir) is an antiviral medication for herpes simplex virus. Valaciclovir is a prodrug of aciclovir formulated to make it more orally bioavailable.

Found 8 search result(s) for aciclovir OR acyclovir OR valaciclovir.

Page: prodrug (HIV/AIDS Research: Its History & Future Meeting)
... reformulation of an existing drug that changes how and where the drug takes effect in the body. Valaciclovir, for example, is absorbed by cells and converted to aciclovir within the cell, making it more orally bioavailable; aciclovir, in turn, is now limited largely to topical use
Jan 11, 2021
Page: Tools, materials, proteins, drugs, and treatments (HIV/AIDS Research: Its History & Future Meeting)
... nucleosides." Prodrugs (drugs that are reformulated to alter their bioavailability) are listed under their "original," i.e. valaciclovir is listed under aciclovir. Specific combination drugs are not indexed
Feb 03, 2021
Page: 3.4 Raymond Schinazi — Discovery and Development of Novel NRTIs (HIV/AIDS Research: Its History & Future Meeting)
... do work. She would send me dry powder to try, including acyclovir to work in my lab, and being able to work on combination chemotherapy for herpes virus ...
Apr 27, 2021
Page: 3.1 Marty St. Clair: Discovery of AZT as the First Anti-HIV Drug (HIV/AIDS Research: Its History & Future Meeting)
... We had—we, being Burroughs Wellcome—had just gotten the approval of aciclovir for herpesviruses. In fact, when I started working for Burroughs Wellcome in 1976, my ...
Apr 27, 2021
Page: 3.6 John C. Martin — Making it Simpler: A Single Pill to Treat HIV (HIV/AIDS Research: Its History & Future Meeting)
... You can see ganciclovir is a little bit closer to 2′deoxyguanosine than acyclovir. That leads to quite a bit of toxicity, Ganciclovir’s 3’OH gets incorporated in DNA ...
Apr 27, 2021
Page: nucleosides, nucleotides, nucleoside analogues, nucleoside reverse transcriptase inhibitors (NRTIs), nucs (HIV/AIDS Research: Its History & Future Meeting)
... manmade molecule that mimics natural nucleosides, either by altering the nucleobase or the sugar. For example, acyclovir is a guanosine ("G") analogue, in that both have a guanine nucleobase, but has a replacement for the ribose ...
Jan 18, 2021
Page: 3.2 Samuel Broder: The First Clinical Trials of Antiretroviral Drugs (HIV/AIDS Research: Its History & Future Meeting)
... hesitation at all, I don't think, from the company at all. I think the aciclovir success, the fact that they had followup drugs with aciclovir and now they were moving into a new era that the precedent would hold. I just ...
Apr 27, 2021
Page: Session 7: Prospects for an HIV Vaccine (HIV/AIDS Research: Its History & Future Meeting)
... Trudy Elion (1918–1999) came to me in Seattle and dropped this drug called the aciclovir in my lab. We rapidly put it through its paces. We were ...
Apr 27, 2021

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