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CAPRISA 004 was a phase II trial of topically applied tenofovir gel for HIV prevention in women, conducted from 2007 to 2009, with publication of results in 2010. CAPRISA 004 was the first clinical trial to show effectiveness of a vaginal gel for HIV prevention.

See Abdool Karim, Quarraisha, Salim S. Abdool Karim, Janet A. Frohlich, Anneke C. Grobler, Cheryl Baxter, Leila E. Mansoor, Ayesha B. M. Kharsany, et al. “Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women.” Science 329, no. 5996 (September 3, 2010): 1168–74. doi:10.1126/science.1193748.

Found 4 search result(s) for CAPRISA.

Page: Abdool Karim, Quarraisha (b. 1960) (HIV/AIDS Research: Its History & Future Meeting)
... Quarraisha Abdool Karim is the Associate Scientific Director of CAPRISA and Professor of Clinical Epidemiology at Columbia University. She is the wife of Salim Abdool Karim ...
Feb 18, 2021
Page: 6.7 Salim Abdool Karim — Stopping the Spread of HIV in Developing Countries (HIV/AIDS Research: Its History & Future Meeting)
... thereafter, in response to the NIH call under the CIPRA banner, we applied to create CAPRISA at the University of KwaZuluNatal, Nelson Mandela Medical School in partnership with 00:07:00 ...
Apr 27, 2021
Page: 6.1 Sharon Hillier — Development and Application of Pre-exposure Prophylaxis (PrEP) (HIV/AIDS Research: Its History & Future Meeting)
... product could be effective by 00:09:00 Salim Karim and his team in the CAPRISA 004 study (2007–2010) with a 39% efficacy with broad confidence intervals. (14 ...
Apr 27, 2021

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