The STEP study was a phase 2 clinical trial (double blinded, randomized, placebo controlled) of the Merck MRKAd5 HIV-1 Gag/Pol/Nef trivalent vaccine, conducted from 2004 to 2007, and with results published in 2011-2012. The trial was halted early once it was found that the experimental vaccine was not effective, and might possibly increase the risk of HIV infection.
See Fitzgerald, D. W., H. Janes, M. Robertson, R. Coombs, I. Frank, P. Gilbert, M. Loufty, D. Mehrotra, A. Duerr, and for the Step Study Protocol Team. “An Ad5-Vectored HIV-1 Vaccine Elicits Cell-Mediated Immunity but Does Not Affect Disease Progression in HIV-1–Infected Male Subjects: Results From a Randomized Placebo-Controlled Trial (The Step Study).” The Journal of Infectious Diseases 203, no. 6 (March 15, 2011): 765–72. doi:10.1093/infdis/jiq114.
Found 2 search result(s) for "STEP study".
... figure because it's a clean figure. What you'll recall what happened in the STEP study is that, in fact, not only was there no protection comparing placebo to the vaccines, but in individuals who had a preexisting ... 16, 17, 18) What I wanted to point out was one particular ...
Apr 27, 2021
... met the immunological bar 00:18:00 and that if we didn’t do the Merck study (STEP study, 2004–2011), we would be dead for a decade. I’m going to now ask ... all be fairly irrelevant in the end, anyway. This all changed completely in 2007 when in the ...
Apr 27, 2021